Literature summary for 2.5.1.15 extracted from

Cambau, E.; Carthagena, L.; Chauffour, A.; Ji, B.; Jarlier, V.
Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy (2006), Clin. Infect. Dis., 42, 238-241.

Search for more literature for 2.5.1.15

Protein Variants

Protein Variants	Comment	Organism
additional information	detection of mutations to predict dapsone resistance	Mycobacterium leprae
P55A	mutation associated with dapsone resistance	Mycobacterium leprae
P55L	mutation associated with dapsone resistance	Mycobacterium leprae
T53A	mutation associated with dapsone resistance	Mycobacterium leprae
T53I	mutation associated with dapsone resistance	Mycobacterium leprae
T53V	mutation associated with dapsone resistance	Mycobacterium leprae

Inhibitors

Inhibitors	Comment	Organism	Structure
dapsone	-	Mycobacterium leprae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate	Mycobacterium leprae	-	diphosphate + 7,8-dihydropteroate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium leprae	P0C0X2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate	-	Mycobacterium leprae	diphosphate + 7,8-dihydropteroate	-	?

Synonyms

Synonyms	Comment	Organism
7,8-dihydropteroate synthase	-	Mycobacterium leprae
DHPS	-	Mycobacterium leprae
dihydropteroate synthetase	-	Mycobacterium leprae
folP1	-	Mycobacterium leprae

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Release 2023.1 (January 2023)