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Literature summary for 2.5.1.15 extracted from

  • Fernley, R.T.; Iliades, P.; Macreadie, I.
    A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors (2007), Anal. Biochem., 360, 227-234.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information coupled enzymatic spectrophotometric assay to measure the activity of DHPS Saccharomyces cerevisiae
P559S mutant with implicated sulfa drug resistance Saccharomyces cerevisiae
T557A mutant with implicated sulfa drug resistance Saccharomyces cerevisiae
T557A/P559S mutant with implicated sulfa drug resistance Saccharomyces cerevisiae
T557V/P559S mutant with implicated sulfa drug resistance Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
dapsone
-
Saccharomyces cerevisiae
sulfachloropyridazine
-
Saccharomyces cerevisiae
sulfamethoxazole
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
p-Aminobenzoic acid wild type Saccharomyces cerevisiae
0.0485
-
p-Aminobenzoic acid mutant P559S Saccharomyces cerevisiae
0.103
-
p-Aminobenzoic acid mutant T557A Saccharomyces cerevisiae
1.161
-
p-Aminobenzoic acid mutant T557V/P559S Saccharomyces cerevisiae
4.02
-
p-Aminobenzoic acid mutant T557A/P559S Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Saccharomyces cerevisiae
-
diphosphate + 7,8-dihydropteroate
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P53848
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Saccharomyces cerevisiae diphosphate + 7,8-dihydropteroate
-
?

Synonyms

Synonyms Comment Organism
7,8-dihydropteroate synthase
-
Saccharomyces cerevisiae
DHPS
-
Saccharomyces cerevisiae
dihydropteroate synthase
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00068
-
dapsone wild tpye Saccharomyces cerevisiae
0.00205
-
dapsone mutant T557A Saccharomyces cerevisiae
0.00295
-
sulfachloropyridazine wild tpye Saccharomyces cerevisiae
0.00371
-
sulfamethoxazole mutant T557A Saccharomyces cerevisiae
0.0063
-
sulfachloropyridazine mutant T557A Saccharomyces cerevisiae
0.0085
-
sulfamethoxazole wild tpye Saccharomyces cerevisiae
0.0148
-
dapsone mutant P559S Saccharomyces cerevisiae
0.0513
-
sulfachloropyridazine mutant P559S Saccharomyces cerevisiae
0.0543
-
sulfamethoxazole mutant P559S Saccharomyces cerevisiae
0.096
-
sulfachloropyridazine mutant T557A/P559S Saccharomyces cerevisiae
0.76
-
sulfamethoxazole mutant T557V/P559S Saccharomyces cerevisiae
0.94
-
sulfachloropyridazine mutant T557V/P559S Saccharomyces cerevisiae
1.16
-
dapsone mutant T557A/P559S Saccharomyces cerevisiae
1.17
-
sulfamethoxazole mutant T557A/P559S Saccharomyces cerevisiae
1.29
-
dapsone mutant T557V/P559S Saccharomyces cerevisiae