Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sulfamethoxazole | competitive to 4-aminobenzoate | Escherichia coli | |
sulfanilamide | - |
Escherichia coli | |
sulfathiazole | competitive to 4-aminobenzoate | Escherichia coli | |
sulfonamide | competitive to 4-aminobenzoate | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00012 | - |
sulfamethoxazole | - |
Escherichia coli | |
0.00057 | - |
4-Aminobenzoate | - |
Escherichia coli | |
0.001 | - |
sulfathiazole | - |
Escherichia coli | |
0.0048 | - |
sulfanilamide | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Escherichia coli | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Escherichia coli B / ATCC 11303 | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole | Escherichia coli | - |
diphosphate + dihydropterin-sulfamethoxazole | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole | Escherichia coli B / ATCC 11303 | - |
diphosphate + dihydropterin-sulfamethoxazole | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration on Sephadex G-100 | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1 | 2 | - |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Escherichia coli | diphosphate + 7,8-dihydropteroate | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Escherichia coli B / ATCC 11303 | diphosphate + 7,8-dihydropteroate | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole | - |
Escherichia coli | diphosphate + dihydropterin-sulfamethoxazole | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole | - |
Escherichia coli B / ATCC 11303 | diphosphate + dihydropterin-sulfamethoxazole | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfanilamide | - |
Escherichia coli | diphosphate + dihydropterin-sulfanilamide | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfathiazole | - |
Escherichia coli | diphosphate + dihydropterin-sulfathiazole | - |
? | |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfathiazole | - |
Escherichia coli B / ATCC 11303 | diphosphate + dihydropterin-sulfathiazole | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
sulfamethoxazole | - |
Escherichia coli | |
0.00053 | - |
sulfonamide | - |
Escherichia coli | |
0.0057 | - |
sulfanilamide | - |
Escherichia coli |