Inhibitors | Comment | Organism | Structure |
---|---|---|---|
([Cu(II)(pamidronate)]H2O)n | - |
Trypanosoma cruzi | |
alendronate | i.e. 4-amino-1-hydroxybutane-1,1-diylphosphonic acid | Trypanosoma cruzi | |
pamidronate | i.e. 3-amino-1-hydroxypropane-1,1-diylphosphonic acid | Trypanosoma cruzi | |
risedronate | i.e. 1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diylphosphonic acid | Trypanosoma cruzi | |
[Co(II)(pamidronate)2(H2O)2] | - |
Trypanosoma cruzi | |
[Co(II)(risedronate)2] | - |
Trypanosoma cruzi | |
[Co(II)2(alendronate)4(H2O)2] | - |
Trypanosoma cruzi | |
[Cu(II)(risedronate)2] | - |
Trypanosoma cruzi | |
[Cu(II)2(alendronate)4(H2O)2] | - |
Trypanosoma cruzi | |
[Mn(II)(pamidronate)2(H2O)2] | - |
Trypanosoma cruzi | |
[Mn(II)(risedronate)2] | - |
Trypanosoma cruzi | |
[Mn(II)2(alendronate)4(H2O)2] | - |
Trypanosoma cruzi | |
[Ni(II)(pamidronate)2(H2O)2] | - |
Trypanosoma cruzi | |
[Ni(II)(risedronate)2] | - |
Trypanosoma cruzi | |
[Ni(II)2(alendronate)4(H2O)2] | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | - |
Trypanosoma cruzi | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
farnesyl diphosphate synthase | - |
Trypanosoma cruzi |
FPPS | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000027 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Mn(II)(risedronate)2] | |
0.0000029 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Ni(II)(risedronate)2] | |
0.000026 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Cu(II)(risedronate)2] | |
0.000027 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | risedronate | |
0.000095 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | ([Cu(II)(pamidronate)]H2O)n | |
0.0001 | - |
IC50 above 0.0001 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Co(II)(risedronate)2] | |
0.000128 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Mn(II)2(alendronate)4(H2O)2] | |
0.000161 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Mn(II)(pamidronate)2(H2O)2] | |
0.000167 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Ni(II)2(alendronate)4(H2O)2] | |
0.000215 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Co(II)(pamidronate)2(H2O)2] | |
0.000328 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Ni(II)(pamidronate)2(H2O)2] | |
0.000717 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Cu(II)2(alendronate)4(H2O)2] | |
0.00134 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | pamidronate | |
0.0044 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | alendronate | |
0.05 | - |
IC50 above 0.05 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | [Co(II)2(alendronate)4(H2O)2] |