Literature summary for 2.4.2.8 extracted from

Patel, M.B.; Kumar, S.P.; Valand, N.N.; Jasrai, Y.T.; Menon, S.K.
Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme (2013), J. Mol. Model., 19, 3201-3217.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2-methyl-4-oxo-(3H) quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	78.12% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
4-(2-methyl-6,8-dibromo-4-oxo-(3H)quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	79.07% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
4-(2-methyl-6-bromo-4-oxo-(3H) quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	77.06% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
4-(2-phenyl-4-oxo-(3H) quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	79.42% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
4-(2-phenyl-6,8-dibromo-4-oxo-(3H)quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	79.71% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
4-(2-phenyl-6-bromo-4-oxo-(3H) quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide	79.55% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
isoniazid	99% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis
rifampicin	99% inhibition at 0.25 mg/ml	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Mycobacterium tuberculosis H37Rv	-	-	-

Synonyms

Synonyms	Comment	Organism
HGPRT	-	Mycobacterium tuberculosis
hypoxanthine-guanine phosphoribosyltransferase	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)