Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C32-TG cell | amelanotic human melanoma cell, hypoxanthine phosphoribosyltransferase-negative | Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | treatment of cells with guanosine and GMP results in statistically significant decreases in cell growth after 48 h and 72 h in the melanoma cell line C32 and in the U-87 glioma cell line. Presence of hypoxanthine blocks the antiproliferative effects. Hypoxanthine phosphoribosyltransferase-negative cell line C32-TG cells completely has lost the inhibitory response to guanine treatment. Hypoxanthine phosphoribosyltransferase silencing by siRNA is able to partially block the guanine-induced antiproliferative effects in U-87 glioma cell lines | Homo sapiens |