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Literature summary for 2.4.2.4 extracted from
- Mycoplasma pneumoniae thymidine phosphorylase (2014), Nucleosides Nucleotides Nucleic Acids, 33, 296-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-fluorocytosine | - |
Mycoplasma pneumoniae |  |
| 5-fluorodeoxyuridine | - |
Mycoplasma pneumoniae | |
| 5-fluorouracil | - |
Mycoplasma pneumoniae | |
| 5-iododeoxyuridine | - |
Mycoplasma pneumoniae | |
| 6-thioguanine | - |
Mycoplasma pneumoniae | |
| acyclovir | - |
Mycoplasma pneumoniae | |
| Cidofovir | - |
Mycoplasma pneumoniae | |
| dipyridamole | - |
Mycoplasma pneumoniae | |
| gancyclovir | - |
Mycoplasma pneumoniae | |
| gemcitabine | - |
Mycoplasma pneumoniae | |
| additional information | not inhibited by pyrimethamine, fludarabine phosphate, lamivudine, adefovir depivoxil, 5-azacytidine, azathioprine, arabinosyl adenine, zalcitabine, caffeine, 7-(2,3-dihydroxypropyl)theophylline, theophylline, allopurinol, 6-mercaptopurine, and valacyclovir | Mycoplasma pneumoniae | |
| mycophenolate mofetil | - |
Mycoplasma pneumoniae | |
| pentoxifylline | - |
Mycoplasma pneumoniae | |
| ribavirin | - |
Mycoplasma pneumoniae | |
| stavudine | - |
Mycoplasma pneumoniae | |
| trifluorothymidine | - |
Mycoplasma pneumoniae | |
| zidovudine | - |
Mycoplasma pneumoniae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymidine + phosphate | Mycoplasma pneumoniae | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
| thymidine + phosphate | Mycoplasma pneumoniae M129 | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycoplasma pneumoniae | P75052 | - |
- |
| Mycoplasma pneumoniae M129 | P75052 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymidine + phosphate | - |
Mycoplasma pneumoniae | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
| thymidine + phosphate | - |
Mycoplasma pneumoniae M129 | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deoA | - |
Mycoplasma pneumoniae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | thymidine phosphorylase is not essential for Mycoplasma pneumoniae survival | Mycoplasma pneumoniae |
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Release 2023.1 (January 2023)
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