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Literature summary for 2.4.2.4 extracted from

  • Ko, J.C.; Chiu, H.C.; Syu, J.J.; Jian, Y.J.; Chen, C.Y.; Jian, Y.T.; Huang, Y.J.; Wo, T.Y.; Lin, Y.W.
    Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine phosphorylase expression in human non-small-cell lung cancer cells (2014), Biochem. Pharmacol., 88, 119-127.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymidine + phosphate Homo sapiens
-
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H-1975 cell
-
Homo sapiens
-
H-520 cell
-
Homo sapiens
-
non-small cell lung cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?

Expression

Organism Comment Expression
Homo sapiens treatment with 0.005-0.04 mM tamoxifen decreases mRNA and protein levels through AKT inactivation down

General Information

General Information Comment Organism
malfunction knocking down enzyme expression enhances the cytotoxicity and cell growth inhibition of tamoxifen Homo sapiens