Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.4 extracted from

  • Khan, K.M.; Ambreen, N.; Hussain, S.; Perveen, S.; Choudhary, M.I.
    Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors (2009), Bioorg. Med. Chem., 17, 2983-2988.
    View publication on PubMed
Search for more literature for 2.4.2.4

Inhibitors

Inhibitors Comment Organism Structure
3-([(1-benzyl-2-hydroxyethyl)imino]methyl)-4Hchromen-4-one
-
 Escherichia coli
3-([(2, 4-dichlorophenyl)imino]methyl)-4H-chromen-4-one
-
 Escherichia coli
3-([(2-([-(4-oxo-4H-chromen-3-yl)methylidene]amino)ethyl)imino] methyl)-4H-chromen-4-one
-
 Escherichia coli
3-([(2-benzoyl-4-chlorophenyl)imino]methyl)-4Hchromen-4-one
-
 Escherichia coli
3-([(2-methyl-6-nitrophenyl)imino]methyl)-4Hchromen-4-one
-
 Escherichia coli
3-([(3-hydroxy-2-pyridinyl)imino]methyl)-4H-chromen-4-one
-
 Escherichia coli
3-([(3-methoxy-4-methylphenyl)imino]methyl)-4Hchromen-4-one
-
 Escherichia coli
3-([(3-methylphenyl)imino]methyl)-4H-chromen-4-one
-
 Escherichia coli
7-deazaxanthine
-
 Escherichia coli
additional information Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors, no inhibition by 3-formylchromone and 3-methyl-7-hydroxychromone, and by derivatives 3-[(4-pyridinylimino) methyl]-4H-chromen-4-one, 3-[(3-pyridinylimino) methyl]-4H-chromen-4-one, 3-([(3-methoxyphenyl)imino]methyl)-4H-chromen-4-one, 3-([(2-methoxy-4-nitrophenyl) imino] methyl)-4Hchromen-4-one, 2-([-(4-oxo-4H-chromen-3-yl) methylidene]amino)benzoic acid, 3-([(4-methylphenyl)imino]methyl)-4H-chromen-4-one, 3-([(2,6-dimethylphenyl)imino]methyl)-4H-chromen-4-one, and 3-[bis(tert-butylamino)methyl]-4H-chromen-4-one, overview Escherichia coli
N'-[-(4-oxo-4H-chromen-3-yl)methylidene]propanohydrazide
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Escherichia coli
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
 pH 7.6 Escherichia coli 3-([(3-methoxy-4-methylphenyl)imino]methyl)-4Hchromen-4-one
0.0393
-
-
 Escherichia coli 7-deazaxanthine
0.04
-
 pH 7.6 Escherichia coli 3-([(2, 4-dichlorophenyl)imino]methyl)-4H-chromen-4-one
0.067
-
 pH 7.6 Escherichia coli 3-([(3-methylphenyl)imino]methyl)-4H-chromen-4-one
0.076
-
 pH 7.6 Escherichia coli 3-([(2-benzoyl-4-chlorophenyl)imino]methyl)-4Hchromen-4-one
0.146
-
 pH 7.6 Escherichia coli N'-[-(4-oxo-4H-chromen-3-yl)methylidene]propanohydrazide
0.15
-
 pH 7.6 Escherichia coli 3-([(2-([-(4-oxo-4H-chromen-3-yl)methylidene]amino)ethyl)imino] methyl)-4H-chromen-4-one
0.34
-
 pH 7.6 Escherichia coli 3-([(3-hydroxy-2-pyridinyl)imino]methyl)-4H-chromen-4-one
0.473
-
 pH 7.6 Escherichia coli 3-([(1-benzyl-2-hydroxyethyl)imino]methyl)-4Hchromen-4-one
0.48
-
 pH 7.6 Escherichia coli 3-([(2-methyl-6-nitrophenyl)imino]methyl)-4Hchromen-4-one