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Literature summary for 2.4.2.4 extracted from

  • Akiyama, S.; Furukawa, T.; Sumizawa, T.; Takebayashi, Y.; Nakajima, Y.; Shimaoka, S.; Haraguchi, M.
    The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression (2004), Cancer Sci., 95, 851-857.
    View publication on PubMed

Application

Application Comment Organism
medicine tumor-associated macrophages that express thymidine phosphorylase may be a good target for chermotherapy of thymidine phosphorylase positive solid tumors Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme complexed with TPI Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-O-tritylinosine
-
Homo sapiens
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride
-
Homo sapiens
7-deazaxanthine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymidine + phosphate Homo sapiens the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors thymine + 2-deoxy-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
gliostatin
-
Homo sapiens
PD-ECGF
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride
-
Homo sapiens