Any feedback?
Literature summary for 2.4.2.4 extracted from
- The activity of thymidine phosphorylase obtained from human uterine leiomyomas and studied in the presence of pyrimidine derivatives (1997), Z. Naturforsch. c, 52, 670-675.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4,6-dihydroxy-5-nitropyrimidine | 0.1 mM, competitive | Homo sapiens |  |
| 5-Bromouracil | 0.1 mM, competitive | Homo sapiens | |
| 5-fluorouracil | 0.1 mM, competitive | Homo sapiens | |
| 5-Nitrouracil | 0.1 mM, competitive | Homo sapiens | |
| 6-aminouracil | 0.1 mM, competitive | Homo sapiens | |
| 6-benzyl-2-thiouracil | 0.1 mM, mixed inhibition | Homo sapiens | |
| allyloxymethylthymine | 0.1 mM, uncompetitive | Homo sapiens | |
| Uracil | inhibits activity in turmor tissue, but not in normal tissue | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.65 | - |
thymidine | normal tissue | Homo sapiens | |
| 9.3 | - |
thymidine | tumor tissue | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterus | normal and tumor tissue | Homo sapiens | - |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0011 | - |
5-Bromouracil | tumor tissue | Homo sapiens | |
| 0.0051 | - |
5-Nitrouracil | tumor tissue | Homo sapiens | |
| 0.006 | - |
5-Bromouracil | normal tissue | Homo sapiens | |
| 0.021 | - |
4,6-dihydroxy-5-nitropyrimidine | tumor tissue | Homo sapiens | |
| 0.0253 | - |
5-Nitrouracil | normal tissue | Homo sapiens | |
| 0.043 | - |
5-fluorouracil | tumor tissue | Homo sapiens | |
| 0.0728 | - |
5-fluorouracil | normal tissue | Homo sapiens | |
| 0.075 | - |
6-benzyl-2-thiouracil | tumor tissue | Homo sapiens | |
| 0.088 | - |
6-aminouracil | tumor tissue | Homo sapiens | |
| 0.127 | - |
allyloxymethylthymine | tumor tissue | Homo sapiens | |
| 0.1286 | - |
allyloxymethylthymine | normal tissue | Homo sapiens | |
| 0.13 | - |
6-aminouracil | normal tissue | Homo sapiens | |
| 0.137 | - |
6-benzyl-2-thiouracil | normal tissue | Homo sapiens | |
| 0.158 | - |
Uracil | tumor tissue | Homo sapiens | |
| 0.211 | - |
4,6-dihydroxy-5-nitropyrimidine | normal tissue | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
