Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Aquifex aeolicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | 4.1 mM, 50% inhibition | Aquifex aeolicus | |
AMP | 6.12 mM, 50% inhibition | Aquifex aeolicus | |
GDP | 8.5 mM, 50% inhibition | Aquifex aeolicus | |
GMP | IC50: 7.9 mM | Aquifex aeolicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.87 | - |
5-phospho-alpha-D-ribose 1-diphosphate | at 90°C | Aquifex aeolicus | |
3 | - |
L-glutamine | at 90°C | Aquifex aeolicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aquifex aeolicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Aquifex aeolicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O | - |
Aquifex aeolicus | 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
90 | - |
both glutaminase and amidotransferase activity | Aquifex aeolicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
glutaminase half-life: 25 h | Aquifex aeolicus |
80 | - |
glutaminase half-life: 65 min | Aquifex aeolicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | glutaminase activity | Aquifex aeolicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
7.9 | - |
IC50: 7.9 mM | Aquifex aeolicus | GMP |