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Literature summary for 2.4.2.1 extracted from
- Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase (2015), Proc. Natl. Acad. Sci. USA, 112, 11247-11251.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.092 | - |
guanosine | native enzyme, at pH 7.4 and 25°C | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| purine deoxyribonucleoside + phosphate | Homo sapiens | - |
purine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
| purine ribonucleoside + phosphate | Homo sapiens | - |
purine + alpha-D-ribose 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + phosphate | - |
Homo sapiens | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| guanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r | |
| purine deoxyribonucleoside + phosphate | - |
Homo sapiens | purine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
| purine ribonucleoside + phosphate | - |
Homo sapiens | purine + alpha-D-ribose 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PNP | - |
Homo sapiens |
| purine nucleoside phosphorylase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 13.4 | - |
guanosine | native enzyme, at pH 7.4 and 25°C | Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 150 | - |
guanosine | native enzyme, at pH 7.4 and 25°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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