Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone | multisubstrate analogue inhibitor | Bos taurus | |
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone | multisubstrate analogue inhibitor | Homo sapiens | |
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine | multisubstrate analogue inhibitor | Bos taurus | |
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine | multisubstrate analogue inhibitor | Homo sapiens | |
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine | multisubstrate analogue inhibitor | Bos taurus | |
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine | multisubstrate analogue inhibitor | Homo sapiens | |
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine | multisubstrate analogue inhibitor | Bos taurus | |
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine | multisubstrate analogue inhibitor | Homo sapiens | |
9-deazaguanine | multisubstrate analogue inhibitor | Bos taurus | |
9-deazaguanine | multisubstrate analogue inhibitor | Homo sapiens | |
additional information | multisubstrate analogue inhibitors with 9-deazaguanine aglycone have better anti-leukaemic and anti-lymphoma activities compared to the guanine and hypoxanthine analogues, and applied in the concentration of 100 microM, cause a statistically significant decrease in the cell viability in all human leukemia and lymphoma cells used. No differences are observed between the effects on the growth of tumour cells sensible to the inhibition of purine nucleoside phosphorylase, such as human adult T-cell leukemia and lymphoma cells, and other investigated cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | - |
Homo sapiens | - |
erythrocyte | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
HUT-78 cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
MOLT cell | - |
Homo sapiens | - |
RAJI cell | - |
Homo sapiens | - |
spleen | of calf | Bos taurus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000044 | - |
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine | pH 7.0, 25°C | Bos taurus | |
0.0000053 | - |
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine | erythrocyte enzyme, pH 7.0, 25°C | Homo sapiens | |
0.0000056 | - |
9-deazaguanine | erythrocyte enzyme, pH 7.0, 25°C | Homo sapiens | |
0.0000057 | - |
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine | pH 7.0, 25°C | Bos taurus | |
0.0000061 | - |
9-deazaguanine | pH 7.0, 25°C | Bos taurus | |
0.0000072 | - |
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone | erythrocyte enzyme, pH 7.0, 25°C | Homo sapiens | |
0.0000075 | - |
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine | pH 7.0, 25°C | Bos taurus | |
0.0000076 | - |
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine | erythrocyte enzyme, pH 7.0, 25°C | Homo sapiens | |
0.0000081 | - |
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine | erythrocyte enzyme, pH 7.0, 25°C | Homo sapiens | |
0.0000112 | - |
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone | pH 7.0, 25°C | Bos taurus |