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Literature summary for 2.4.2.1 extracted from

  • Kamath, V.P.; Xue, J.; Juarez-Brambila, J.J.; Morris, C.B.; Ganorkar, R.; Morris, P.E.
    Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I (2009), Bioorg. Med. Chem. Lett., 19, 2624-2626.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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Homo sapiens
7-[(2S,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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Homo sapiens
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one i.e. forodesine Homo sapiens
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
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IC50 values of compounds 6-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, and 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid are in the range of 100-300 nM Homo sapiens additional information