Protein Variants | Comment | Organism |
---|---|---|
K22E/H104R | the transition state of the mutant is fully dissociative, N7-protonated hypoxanthine with C1'-N9 distance above 3.0 A, with partial participation of phosphate, C1-Ophosphate distance is 2.26 A, 2'-C-exo-ribosyl ring pucker and the O5'-C5'-C4'-O4' dihedral angle near 60°. The transition state of the mutant is altered from the fully dissociative DN*AN character for the human wild-type purine nucleoside phosphorylase to a late phosphate-associative character | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |