Literature summary for 2.4.2.1 extracted from

Pereira, H.M.; Berdini, V.; Ferri, M.R.; Cleasby, A.; Garratt, R.C.
Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor (2010), Acta Trop., 114, 97-102.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor 6-amino-5-bromopyrimidine-2,4(1H,3H)-dione, to 1.9 A resolution	Schistosoma mansoni

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]guanidine	0.1 mM , 79.5% inhibition	Schistosoma mansoni
1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]guanidine	0.1 mM , 70.6% inhibition	Schistosoma mansoni
6-amino-5-bromopyrimidine-2,4(1H,3H)-dione	formation of eight hydrogen bonds with key residues in the active site E203, N245 and T244	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	Q9BMI9	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0013	-	pH 7.0	Schistosoma mansoni	6-amino-5-bromopyrimidine-2,4(1H,3H)-dione

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Release 2023.1 (January 2023)