Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-ketopyrazolo[4,3-d]pyrimidine | inhibits phosphorolysis of 7-methylguanosine uncompetitively, inhibits synthesis of 8-azaguanosine competitively | Bos taurus | |
7KPP | non-substrate inhibitor of both the phosphorolytic and reverse synthetic pathways, inhibits synthesis of 8-azaguanosine from 8-azaguanine competitively | Bos taurus | |
formycin B | inhibits phosphorolysis of 7-methylguanosine uncompetitively; weak, uncompetitive inhibitor. Formycin B forms a weakly fluorescent complex with the enzyme | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Bos taurus | - |
calf | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spleen | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-methylguanosine + phosphate | - |
Bos taurus | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
8-azaguanine + alpha-D-ribose 1-phosphate | - |
Bos taurus | 8-azaguanosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PNP | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 7.3, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM | Bos taurus | |
0.0028 | 0.0035 | 7-ketopyrazolo[4,3-d]pyrimidine | pH 6.5, concentration of the substrate 8-azaguanosine is 0.05-0.25 mM | Bos taurus | |
0.0036 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 7.9, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM | Bos taurus | |
0.0037 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 8.2, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM | Bos taurus | |
0.0042 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 8.2, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM | Bos taurus | |
0.038 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 6.0, concentration of the substrate 7-methylguanosine is 0.032 mM | Bos taurus | |
0.054 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 7.0, concentration of the substrate 7-methylguanosine is 0.03 mM | Bos taurus | |
0.073 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 7.0, concentration of the substrate 7-methylguanosine is 0.122 mM | Bos taurus | |
0.093 | - |
7-ketopyrazolo[4,3-d]pyrimidine | pH 8.0, concentration of the substrate 7-methylguanosine is 0.032 mM | Bos taurus | |
0.1 | - |
formycin B | inhibition of phosphorolysis of 7-methylguanosine | Bos taurus | |
0.1 | - |
formycin B | phosphorolysis of 7-methylguanosine | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | 0.004 | synthesis of 8-azaguanosine from 8-azaguanine | Bos taurus | 7KPP | |
0.035 | 0.1 | phosphorolysis of 7-methylguanosine | Bos taurus | 7KPP | |
0.098 | - |
pH 7.0, concentration of the substrate 7-methylguanosine is 0.03 mM | Bos taurus | 7-ketopyrazolo[4,3-d]pyrimidine | |
0.098 | - |
pH 7.0, concentration of the substrate 7-methylguanosine is 0.122 mM | Bos taurus | 7-ketopyrazolo[4,3-d]pyrimidine |