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Literature summary for 2.4.2.1 extracted from

  • Taylor, E.A.; Rinaldo-Matthis, A.; Li, L.; Ghanem, M.; Hazleton, K.Z.; Cassera, M.B.; Almo, S.C.; Schramm, V.L.
    Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition (2007), Biochemistry, 46, 12405-12415.
    View publication on PubMed
Search for more literature for 2.4.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Anopheles gambiae

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of AgPNP is determined in complex with 5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H and phosphate to a resolution of 2.2 A Anopheles gambiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 2'-deoxyguanosine
-
 Anopheles gambiae
0.187
-
 guanosine
-
 Anopheles gambiae
0.19
-
 2'-deoxyinosine
-
 Anopheles gambiae
0.585
-
 Inosine
-
 Anopheles gambiae

Organism

Organism UniProt Comment Textmining
Anopheles gambiae A4Q998
-
-
Homo sapiens P00491
-
-
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Anopheles gambiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyguanosine + phosphate
-
 Anopheles gambiae guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2'-deoxyinosine + phosphate
-
 Anopheles gambiae alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
-
 ?
guanosine + phosphate
-
 Anopheles gambiae guanine + alpha-D-ribose 1-phosphate
-
 ?
inosine + phosphate
-
 Plasmodium falciparum hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?
inosine + phosphate
-
 Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?
inosine + phosphate
-
 Anopheles gambiae hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?
additional information no activity is detected for adenosine or 2'-deoxyadenosine Anopheles gambiae ?
-
 ?

Synonyms

Synonyms Comment Organism
AgPNP
-
 Anopheles gambiae
HsPNP
-
 Homo sapiens
PfPNP
-
 Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1
-
 guanosine
-
 Anopheles gambiae
5.4
-
 2'-deoxyguanosine
-
 Anopheles gambiae
41
-
 Inosine
-
 Anopheles gambiae
54
-
 2'-deoxyinosine
-
 Anopheles gambiae