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Literature summary for 2.4.2.1 extracted from
- Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases (2007), Curr. Drug Targets, 8, 413-422.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| immucillin-H | - |
Homo sapiens |  |
| immucillin-H | - |
Plasmodium falciparum | |
| immucillin-H | - |
Plasmodium lophurae | |
| immucillin-H | - |
Toxoplasma gondii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
guanine | recombinant erythrocyte enzyme | Homo sapiens | |
| 0.0078 | - |
Inosine | - |
Bos taurus | |
| 0.012 | - |
guanosine | recombinant erythrocyte enzyme | Homo sapiens | |
| 0.016 | - |
7-methylguanosine | - |
Bos taurus | |
| 0.018 | - |
guanosine | - |
Bos taurus | |
| 0.02 | - |
deoxyguanosine | - |
Bos taurus | |
| 0.03 | - |
hypoxanthine | recombinant erythrocyte enzyme | Homo sapiens | |
| 0.04 | - |
Inosine | recombinant erythrocyte enzyme | Homo sapiens | |
| 0.053 | - |
phosphate | - |
Bos taurus | |
| 4 | - |
phosphate | recombinant erythrocyte enzyme | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | P55859 | - |
- |
| Homo sapiens | P00491 | - |
- |
| Plasmodium falciparum | Q8T9Z7 | - |
- |
| Plasmodium lophurae | - |
- |
- |
| Toxoplasma gondii | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-methylguanosine + phosphate | - |
Bos taurus | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
| deoxyguanosine + phosphate | - |
Bos taurus | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| guanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-ribose 1-phosphate | - |
r | |
| guanosine + phosphate | - |
Bos taurus | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r | |
| inosine + phosphate | - |
Bos taurus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bPNO | - |
Bos taurus |
| HsPNO | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | 8 | guanosine | recombinant erythrocyte enzyme | Homo sapiens | |
| 20 | - |
Inosine | - |
Bos taurus | |
| 48 | - |
guanine | recombinant erythrocyte enzyme | Homo sapiens | |
| 56 | - |
phosphate | recombinant erythrocyte enzyme | Homo sapiens | |
| 56 | - |
Inosine | recombinant erythrocyte enzyme | Homo sapiens | |
| 110 | - |
hypoxanthine | recombinant erythrocyte enzyme | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000000072 | - |
immucillin-H | - |
Homo sapiens | |
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