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Literature summary for 2.4.2.1 extracted from
- Purine nucleoside phosphorylase: a target for drug design (1993), Med. Res. Rev., 13, 209-228.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | since PNP inhibitors block the catabolism of purine nucleosides to hypoxanthine and guanine, precursors of uric acid, they should be useful in the treatment of goat and other hyperuricemic conditions. A number of parasites, including the malaria parasite, lacking the ability to synthesize purine nucleotides de novo, must utilize host purines, formed by PBP, for DNA synthesis. Thus inhibition of PNP could prevent the spread of parasitic infection | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 8-aminoguanine | - |
Homo sapiens |  |
| 8-aminoguanosine | - |
Homo sapiens | |
| additional information | inhibition by 9-cycloaliphatic methyl and 9-saturated heterocyclic methyl-9-deazapurines | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | - |
? | - |
? | |
| additional information | Homo sapiens | children lacking PNP activity exhibit severe T cell immunodeficiency while maintaining normal or exaggerated B cell function. The PNP deficiency results in very low uric acid concentrations and high concentrations of the nucleoside substrate of PNP in plasma and urine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8-aminoguanine + alpha-D-ribose 1-phosphate | - |
Homo sapiens | 8-aminoguanosine + phosphate | - |
? | |
| 8-aminoguanine + alpha-D-ribose 1-phosphate | - |
Bos taurus | 8-aminoguanosine + phosphate | - |
? | |
| adenine + deoxyribose 1-phosphate | - |
Homo sapiens | deoxyadenosine + phosphate | - |
r | |
| adenine + deoxyribose 1-phosphate | - |
Bos taurus | deoxyadenosine + phosphate | - |
r | |
| additional information | - |
Bos taurus | ? | - |
? | |
| additional information | children lacking PNP activity exhibit severe T cell immunodeficiency while maintaining normal or exaggerated B cell function. The PNP deficiency results in very low uric acid concentrations and high concentrations of the nucleoside substrate of PNP in plasma and urine | Homo sapiens | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
8-aminoguanine | - |
Homo sapiens | |
| 0.017 | - |
8-aminoguanosine | - |
Homo sapiens | |
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