Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | the enzyme inhibitors 8-amino-5'-deoxy-5'-chloroguanosine and 8-amino-9-benzylguanine may have some antimalarial potential by limiting hypoxanthine production in the parasite-infected erythrocyte | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Homo sapiens | |
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Plasmodium falciparum | |
8-amino-5'-deoxy-5'-chloroguanosine | - |
Homo sapiens | |
8-amino-5'-deoxy-5'-chloroguanosine | - |
Plasmodium falciparum | |
8-Amino-9-benzylguanine | - |
Homo sapiens | |
8-Amino-9-benzylguanine | - |
Plasmodium falciparum | |
8-aminoguanosine | - |
Homo sapiens | |
8-aminoguanosine | - |
Plasmodium falciparum | |
formycin B | - |
Homo sapiens | |
formycin B | - |
Plasmodium falciparum | |
additional information | the enzyme inhibitors 8-amino-5'-deoxy-5'-chloroguanosine and 8-amino-9-benzylguanine may have some antimalarial potential by limiting hypoxanthine production in the parasite-infected erythrocyte | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
Inosine | - |
Plasmodium falciparum | |
0.01 | - |
guanosine | - |
Plasmodium falciparum | |
0.035 | - |
guanosine | - |
Homo sapiens | |
0.038 | - |
deoxyguanosine | - |
Homo sapiens | |
0.041 | - |
Inosine | - |
Homo sapiens | |
0.057 | - |
deoxyguanosine | - |
Plasmodium falciparum | |
0.43 | - |
phosphate | - |
Homo sapiens | |
0.68 | - |
phosphate | - |
Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
147000 | - |
sucrose density gradient centrifugation | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyguanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
deoxyguanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
guanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-ribose 1-phosphate | - |
? | |
guanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-ribose 1-phosphate | - |
? | |
inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
inosine + phosphate | - |
Plasmodium falciparum | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
8-Amino-9-benzylguanine | - |
Homo sapiens | |
0.0004 | - |
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Homo sapiens | |
0.0011 | - |
formycin B | - |
Plasmodium falciparum | |
0.007 | - |
8-aminoguanosine | - |
Homo sapiens | |
0.008 | - |
8-Amino-9-benzylguanine | - |
Plasmodium falciparum | |
0.012 | - |
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Plasmodium falciparum | |
0.013 | - |
8-aminoguanosine | - |
Plasmodium falciparum | |
0.13 | - |
formycin B | - |
Homo sapiens |