Application | Comment | Organism |
---|---|---|
medicine | FUT1 can efficiently prevent the synthesis of slex antigens in hepatocarcinoma and colon carcinoma cells and their interaction with activated endothelia. The FUT-EGFP gene transfer approach would be expected to decrease or even suppress the initial vascular arrest of tumor cells and may provide a basis for the development of antimetastatic gene therapy | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | FUT1 is able to efficiently alpha(1,2)-fucosylate the O-linked glycans of PSGL-1 but not the sLex structures that bind too the P-selectin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BxPC-3 cell | stable transfeceted with FUT1 cDNA in a pcDNA3 vector | Homo sapiens | - |
Hep-G2 cell | stable transfeceted with FUT1 cDNA in a pcDNA3 vector | Homo sapiens | - |
HT-29 cell | stable transfeceted with FUT1 cDNA in a pcDNA3 vector | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | FUT1 is able to efficiently alpha(1,2)-fucosylate the O-linked glycans of PSGL-1 but not the sLex structures that bind too the P-selectin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha(1,2)-fucosyltransferase-I | - |
Homo sapiens |
FUT1 | - |
Homo sapiens |