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Literature summary for 2.4.1.41 extracted from

  • Gomez, H.; Rojas, R.; Patel, D.; Tabak, L.A.; Lluch, J.M.; Masgrau, L.
    A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2 (2014), Org. Biomol. Chem., 12, 2645-2655.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.41

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E334Q the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens
N335A the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens
N335D the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens
N335H the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens
N335S the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens
R362K the mutant shows strongly reduced activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens no activity with 2'-deoxy-alpha-D-galactosamine or 2'-oxymethyl-alpha-D-galactosamine ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2 Homo sapiens sequence PTTDSTTPAPTTK UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q10471
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with 2'-deoxy-alpha-D-galactosamine or 2'-oxymethyl-alpha-D-galactosamine Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2 sequence PTTDSTTPAPTTK Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2
-
 ?

Synonyms

Synonyms Comment Organism
GalNAc-T2
-
 Homo sapiens
UDP-GalNAc polypeptide:GalNAc transferase-T2
-
 Homo sapiens
UDP-N-acetylgalactosamine polypeptide: N-acetylgalactosaminyl-transferase
-
 Homo sapiens