Cloned (Comment) | Organism |
---|---|
pIMKF3 for expression in COS7 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
delta/delta | mice homozygous for ppGalNAcT-1delta allele | Mus musculus |
ppGalNAcT-1delta | allele in transgenic mice that lacks exon 3 and enzymatic activity, crossed into C57BL/6NHsd background | Mus musculus |
wt/delta | mice heterozygous for ppGalNAcT-1delta allele | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + polypeptide | Mus musculus | mucin-type O-linked glycosylation of serine or threonine residues | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform ppGalNAcT-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | redundancy of enzyme activity | Mus musculus | - |
germinal center | ppGalNacT-1 activity is essential for O-glycosylation in germinal center (GC) B cells within the white pulp of the spleen and lymph nodes upon immunization, increased apoptosis of IgG bearing GC B cells and reduced IgG abundance in the absence of ppGalNAcT-1 | Mus musculus | - |
kidney | cloned from mouse kidney total RNA | Mus musculus | - |
leukocyte | ppGalNAcT-1 mediated O-glycosylation contributes to innate immune inflammatory response among activated endothelial cells by expression of cell surface selectin ligands on neutrophils | Mus musculus | - |
lymph node | mostly inguinal lymph nodes, not Peyerยs patch tissue, ppGalNAcT-1 activity regulates L-selectin ligand level in high endothelial venules that is responsible for lymph node cellularity and B- and T-cell homing | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-GalNAc + EA2 | - |
Mus musculus | GalNAc-EA2 + UDP | - |
? | |
UDP-GalNAc + PRFODSSSKAPPPLPSPSRLPG | - |
Mus musculus | GalNAc-PRFODSSSKAPPPLPSPSRLPG + UDP | - |
? | |
UDP-GalNAc + selectin | - |
Mus musculus | GalNAc-selectin + UDP | reduced expression of cell surface E- and P-selectins (fourfold and fivefold) and L-selectins on immune cells of ppGalNAcT-1 deficient mice | ? | |
UDP-N-acetyl-D-galactosamine + polypeptide | mucin-type O-linked glycosylation of serine or threonine residues | Mus musculus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
polypeptide GalNAc transferase | - |
Mus musculus |
polypeptide GalNAcT | - |
Mus musculus |
polypeptide N-acetylgalactosaminyltransferase | - |
Mus musculus |
ppGalNAcT | - |
Mus musculus |