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Literature summary for 2.4.1.41 extracted from

  • Takeuchi, H.; Kato, K.; Hassan, H.; Clausen, H.; Irimura, T.
    O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Distinct specificity of GalNAc-transferase isoforms (2002), Eur. J. Biochem., 269, 6173-6183.
    View publication on PubMed
Search for more literature for 2.4.1.41

Cloned(Commentary)

Cloned (Comment) Organism
expression of GalNAc-T1, -T2 and -T3 as soluble proteins in insect Sf9 cells Homo sapiens
expression of secreted GalNAc-T4 in CHO cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 pp-GalNAc-T1, -T2, -T3 and -T4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information multiple enzyme isoforms Homo sapiens ?
-
 ?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide acceptors: partially glycosylated versions of a peptide derived from mucin2, pp-GalNAc-T1, -T2, -T3 and -T4 exhibit distinct specificities toward glycopeptides, pathway of incorporation of the second and third GalNAc, isoenzymes may recognize directly GalNAc residues in the vicinity Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide acceptor: mucin2 derived fluorescein-conjugated peptide Pro-Thr-Thr-Thr-Pro-Leu-Lys, preferential sites of O-glycosylation by pp-GalNAc-T1, -T2, -T3 and -T4, of which each has a unique specificity Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
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 ?
UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens