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Literature summary for 2.4.1.41 extracted from

  • Iwasaki, H.; Zhang, Y.; Tachibana, K.; Gotoh, M.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Kubota, T.; Narimatsu, H.
    Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (2003), J. Biol. Chem., 278, 5613-5621.
    View publication on PubMed
Search for more literature for 2.4.1.41

Cloned(Commentary)

Cloned (Comment) Organism
cloning of ppGalNAc-T1, -T2, -T3, -T4, -T6 and –T9 and expression as secreted proteins fused with a FLAG peptide in insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens ppGalNAc-T2: initiation of O-glycosylation in the IgA1 hinge region UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant ppGalNAc-T1, -T2, -T3, -T4, -T6 and –T9, expressed in insect cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte cell line expression of ppGalNAc-T1, -T2, -T3, -T4, -T6 and -T9 in B-cells and IgA-bearing B cells Homo sapiens
-
myeloma cell line expression of ppGalNAc-T1, -T2, -T3, -T4, -T6 and -T9 in NCI-H929 IgA myeloma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information at least 11 human ppGalNAc-Ts Homo sapiens ?
-
 ?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGalNAc-T4 and -T7 prefer peptides having GalNAc residues as acceptor substrates Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
-
 ?
UDP-N-acetyl-D-galactosamine + immunoglobulin A1 O-linked glycosylation of the human IgA1 hinge region by ppGalNAc-T2, synthetic IgA hinge peptide: ppGalNAc-T2 shows strongest activity and is able to transfer GalNAc to almost all possible glycosylation sites, other ppGalNAc-Ts show extremely weak activities Homo sapiens UDP + N-acetyl-D-galactosaminyl-immunoglobulin A1
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide substrate specificities of recombinant ppGalNAc-T1, -T2, -T3, -T4, -T6 and –T9 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T2: initiation of O-glycosylation in the IgA1 hinge region Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens