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Literature summary for 2.4.1.41 extracted from

  • Wang, H.; Tachibana, K.; Zhang, Y.; Iwasaki, H.; Kameyama, A.; Cheng, L.; Guo, J.; Hiruma, T.; Togayachi, A.; Kudo, T.; Kikuchi, N.; Narimatsu, H.
    Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 (2003), Biochem. Biophys. Res. Commun., 300, 738-744.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
ppGalNAc-T14 and -T2 are cloned and expressed in Sf21 cells in a secreted form, 2 alternatively spliced isoforms of the ppGalNAc-T14 transcript are sequenced, major splicing form: 552-amino acid protein, ppGalNAc-T14 gene is mapped to chromosome 2p23.2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Homo sapiens 5794
-
membrane ppGalNAc-T14: type II membrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens ppGalNAc-T14 may be involved in O-glycosylation in kidney UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens catalyzes the first step in biosynthesis of O-linked oligosaccharides in many glycoproteins UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
ppGalNAc-T14 and -T2
-

Purification (Commentary)

Purification (Comment) Organism
ppGalNAc-T14 and -T2, expressed in Sf21 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney significantly high expression of ppGalNAc-T14 Homo sapiens
-
additional information ppGalNAc-T14 is ubiquitously expressed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information multiple enzyme isoforms Homo sapiens ?
-
?
additional information 14 distinct isoforms different with regard to their expression and specificity, but overlaps also occur, ppGalNAc-T14 forms together with ppGalNAc-T2 a subfamily of ppGalNAc-T gene family Homo sapiens ?
-
?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGalNAc-T14 can utilize GalNAc transferred peptides as substrates Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
-
?
UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T14: acceptors are mucin-derived peptides such as Muc2, Muc5AC, Muc7, Muc13 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T14 may be involved in O-glycosylation in kidney Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
UDP-N-acetyl-D-galactosamine + polypeptide catalyzes the first step in biosynthesis of O-linked oligosaccharides in many glycoproteins Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens