Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Schwann cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase I | - |
Rattus norvegicus |
beta-1,4-GalT-I | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of beta-1,4-GalT-I represses Schwann cell proliferation induced by low concentration of TNF-alpha via ERK1/2 signal pathway and TNFR2, while knocking down beta-1,4-GalT I expression inhibits Schwann cell apoptosis induced by high concentration of TNF-alpha via P38, JNK signal pathways, and TNFR1 | Rattus norvegicus |
physiological function | beta-1,4-GalT I plays an important role in Schwann cell proliferation and apoptosis induced by TNF-alpha via different signal pathways and TNF-alpha receptor | Rattus norvegicus |