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Literature summary for 2.4.1.38 extracted from

  • Yuan, Q.; Yang, H.; Cheng, C.; Li, C.; Wu, X.; Huan, W.; Sun, H.; Zhou, Z.; Wang, Y.; Zhao, Y.; Lu, X.; Shen, A.
    beta-1,4-Galactosyltransferase I involved in Schwann cells proliferation and apoptosis induced by tumor necrosis factor-alpha via the activation of MAP kinases signal pathways (2012), Mol. Cell. Biochem., 365, 149-158.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Schwann cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
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Rattus norvegicus
beta-1,4-GalT-I
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Rattus norvegicus

General Information

General Information Comment Organism
malfunction overexpression of beta-1,4-GalT-I represses Schwann cell proliferation induced by low concentration of TNF-alpha via ERK1/2 signal pathway and TNFR2, while knocking down beta-1,4-GalT I expression inhibits Schwann cell apoptosis induced by high concentration of TNF-alpha via P38, JNK signal pathways, and TNFR1 Rattus norvegicus
physiological function beta-1,4-GalT I plays an important role in Schwann cell proliferation and apoptosis induced by TNF-alpha via different signal pathways and TNF-alpha receptor Rattus norvegicus