Literature summary for 2.4.1.38 extracted from

Liu, X.; Cheng, C.; Shao, B.; Wu, X.; Ji, Y.; Lu, X.; Shen, A.
The functional interaction between CDK11p58 and beta-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide (2012), Inflammation, 35, 1365-1377.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
beta-1,4-galactosyltransferase I	-	Rattus norvegicus
beta-1,4-GalT-I	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	CDK11p58 and beta-1,4-GalT-I are induced in lipopolysaccharide-challenged rat primary astrocytes in a affinis dose- and time-dependent manner. CDK11p58 regulates the expression of beta-1,4-GalT-I by interacting with it. The expression of beta-1,4-GalT-I increases, and astrocyte activation enhances due to the overexpression of CDK11p58	up

General Information

General Information	Comment	Organism
malfunction	knockdown of beta-1,4-GalT-I reduces the activation potentiation caused by the overexpression of CDK11p58, illustrating the function of CDK11p58 to promote astrocyte activation depends on beta-1,4-GalT-I	Rattus norvegicus

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Release 2023.1 (January 2023)