Literature summary for 2.4.1.38 extracted from

Shen, J.; Jiang, J.; Wei, Y.; Zhou, L.; Liu, D.; Zhou, J.; Gu, J.
Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis (2007), Mol. Cell. Biochem., 304, 361-367.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I through enhancing Sp1 protein expression, and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the constitutively active Akt protein, myr-Akt, inhibits CHX-induced apoptosis in SMMC-7721 cells through downregulating beta1,4GT1	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	-	Homo sapiens	-
SMMC-7721 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
beta1,4-galactosyltransferase I	-	Homo sapiens
beta1,4GT1	-	Homo sapiens

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Release 2023.1 (January 2023)