Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.38 extracted from

  • Ramakrishnan, B.; Qasba, P.K.
    Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates (2007), J. Mol. Biol., 365, 570-576.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.38

Protein Variants

Protein Variants Comment Organism
Y285I site-directed mutagenesis, the mutation converts the betaGALT1 enzyme into an equally efficient beta4GalNAc-T1, EC 2.4.1.90 Homo sapiens
Y285L site-directed mutagenesis, the mutation converts the betaGALT1enzyme into an equally efficient beta4GalNAc-T1, EC 2.4.1.90 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Homo sapiens
-
 UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide residue Y285 alone is responsible for determination of enzyme substrate specificity, overview, active site structure, overview Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase-1
-
 Homo sapiens
betaGALT1
-
 Homo sapiens
GalT1
-
 Homo sapiens
More cf. EC 2.4.1.90 Homo sapiens