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Literature summary for 2.4.1.38 extracted from

  • Machingo, Q.J.; Fritz, A.; Shur, B.D.
    A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish (2006), Dev. Biol., 297, 471-482.
    View publication on PubMed
Search for more literature for 2.4.1.38

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and anaylsis, sequence comparisons Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information knockdown of zebrafish beta-4GalT1 by two independent morpholino oligonucleotides results in embryos with a truncated anterior-posterior axis, as well as elongated somites and moderate defects in the patterning of the head mesenchyme, phenotype with the axial mesoderm of epiboly stage embryos being abnormally widened in beta-4GalT1 morphants, indicative of abnormal convergent extension, laminin isolated from beta-4GalT1 morphant embryos is poorly galactosylated, activity is restored by injection of wild-type enzyme mRNA, overview Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + laminin Danio rerio
-
 UDP + beta-1,4-D-galactosyl-laminin
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo the enzyme is maternally loaded and expressed throughout development, overview Danio rerio
-
oocyte
-
 Danio rerio
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Danio rerio

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + laminin
-
 Danio rerio UDP + beta-1,4-D-galactosyl-laminin
-
 ?

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase I
-
 Danio rerio
beta4GalT1
-
 Danio rerio