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Literature summary for 2.4.1.38 extracted from

  • Chen, W.S.; Chang, H.Y.; Li, C.P.; Liu, J.M.; Huang, T.S.
    Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis (2005), Clin. Cancer Res., 11, 8615-8622.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
colon
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Homo sapiens
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colonic cancer cell of patients with colorectal cancer 48% have down-regulated expression of beta-1,4-GT-IV in the tumor tissue, while 28% of patients exhibit elevated beta-1,4-GT-IV levels, the patient group with tumor beta-1,4-GT-IV overexpression strongly predicts for tumor metastasis, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview Homo sapiens ?
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?
additional information beta-1,4-GTs are a family of glycosyltransferases responsible for biosynthesizing N-acetyllactosamine by the transfer of a galactose from UDP-galactose to the terminal N-acetylgluosamine of acceptor sugars in glycoproteins or glycolipids with a beta-1,4-linkage Homo sapiens ?
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?
UDP-galactose + N-acetylglucosamine
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Homo sapiens UDP + N-acetyllactosamine
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?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase IV
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Homo sapiens
beta-1,4-GT-IV
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Homo sapiens