Cloned (Comment) | Organism |
---|---|
gene UGT1A1, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
gene UGT1A4, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
gene UGT1A9, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
gene UGT2B7, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km values of isozymes using different specific substrates at different concentrations with healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin | Homo sapiens | i.e. SN-38, an active metabolite of irinotecan | UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + genistein | Homo sapiens | - |
UDP + genistein beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | Homo sapiens | - |
UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + tamoxifen | Homo sapiens | - |
UDP + tamoxifen N-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + zidovudine | Homo sapiens | - |
UDP + zidovudine beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | UGT1A9; UGT1A9 | - |
Homo sapiens | P16662 | UGT2B7; UGT2B7 | - |
Homo sapiens | P22309 | UGT1A1; UGT1A1 | - |
Homo sapiens | P22310 | UGT1A4; UGT1A4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin | i.e. SN-38, an active metabolite of irinotecan | Homo sapiens | UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + genistein | - |
Homo sapiens | UDP + genistein beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + tamoxifen | - |
Homo sapiens | UDP + tamoxifen N-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + zidovudine | - |
Homo sapiens | UDP + zidovudine beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT1A1 | - |
Homo sapiens |
UGT1A4 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the complete absence of UGT1A1 activity results in Crigler-Najjar's syndrome type I, brain damage, and even death | Homo sapiens |
physiological function | metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues | Homo sapiens |