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Literature summary for 2.4.1.17 extracted from

  • Lu, L.; Zhou, J.; Shi, J.; Peng, X.J.; Qi, X.X.; Wang, Y.; Li, F.Y.; Zhou, F.Y.; Liu, L.; Liu, Z.Q.
    Drug-metabolizing activity, protein and gene expression of UDP-glucuronosyltransferases are significantly altered in hepatocellular carcinoma patients (2015), PLoS ONE, 10, e0127524.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene UGT1A1, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
gene UGT1A4, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
gene UGT1A9, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
gene UGT2B7, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km values of isozymes using different specific substrates at different concentrations with healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin Homo sapiens i.e. SN-38, an active metabolite of irinotecan UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
-
?
UDP-glucuronate + genistein Homo sapiens
-
UDP + genistein beta-D-glucuronoside
-
?
UDP-glucuronate + propofol Homo sapiens
-
UDP + propofol beta-D-glucuronoside
-
?
UDP-glucuronate + tamoxifen Homo sapiens
-
UDP + tamoxifen N-beta-D-glucuronoside
-
?
UDP-glucuronate + zidovudine Homo sapiens
-
UDP + zidovudine beta-D-glucuronoside
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656 UGT1A9; UGT1A9
-
Homo sapiens P16662 UGT2B7; UGT2B7
-
Homo sapiens P22309 UGT1A1; UGT1A1
-
Homo sapiens P22310 UGT1A4; UGT1A4
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin i.e. SN-38, an active metabolite of irinotecan Homo sapiens UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
-
?
UDP-glucuronate + genistein
-
Homo sapiens UDP + genistein beta-D-glucuronoside
-
?
UDP-glucuronate + propofol
-
Homo sapiens UDP + propofol beta-D-glucuronoside
-
?
UDP-glucuronate + tamoxifen
-
Homo sapiens UDP + tamoxifen N-beta-D-glucuronoside
-
?
UDP-glucuronate + zidovudine
-
Homo sapiens UDP + zidovudine beta-D-glucuronoside
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT1A1
-
Homo sapiens
UGT1A4
-
Homo sapiens
UGT1A9
-
Homo sapiens
UGT2B7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction the complete absence of UGT1A1 activity results in Crigler-Najjar's syndrome type I, brain damage, and even death Homo sapiens
physiological function metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues Homo sapiens