Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose | ? | - |
? | |
UDP-glucuronate + morphine | Homo sapiens | - |
UDP + morphine-3-beta-D-glucuronide | - |
? | |
UDP-glucuronate + morphine | Homo sapiens | - |
UDP + morphine-6-beta-D-glucuronide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16662 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose | Homo sapiens | ? | - |
? | |
UDP-glucuronate + morphine | - |
Homo sapiens | UDP + morphine-3-beta-D-glucuronide | - |
? | |
UDP-glucuronate + morphine | - |
Homo sapiens | UDP + morphine-6-beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose. Morphine-3-beta-D-glucuronide and morphine-6-beta-D-glucuronide are the major metabolites of morphine in humans | Homo sapiens |