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Literature summary for 2.4.1.17 extracted from

  • Sten, T.; Bichlmaier, I.; Kuuranne, T.; Leinonen, A.; Yli-Kauhaluoma, J.; Finel, M.
    UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly (2009), Drug Metab. Dispos., 37, 417-423.
    View publication on PubMed
Search for more literature for 2.4.1.17

Application

Application Comment Organism
medicine some male athletes have testosterone to epitestosterone values greater than the accepted threshold value 4.0, even without testosterone abuse. The main reason for such false-positive results in doping tests is a low epitestosterone glucuronide concentration but not a high level of testosterone glucuronide Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0017
-
 Epitestosterone isoform UGT2B7, pH 7.4, 37°C Homo sapiens
0.01
-
 testosterone isoform UGT2B17, pH 7.4, 37°C Homo sapiens
0.0116
-
 Epitestosterone isoform UGT2A1, pH 7.4, 37°C Homo sapiens
0.0387
-
 testosterone isoform UGT2A1, pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 male athletes
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium nasal epithelium, isoform UGT2A1 Homo sapiens
-
urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epitestosterone + UDP-glucuronate epitestosterone glucuronidation is catalyzed mainly by UGT2B7. No substrate for isoform UGT2B17, but it binds epitestosterone with affinity similar to that of testosterone. Isoform UGT2A1 catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics Homo sapiens UDP + epitestosterone 17-O-glucuronide
-
 ?
testosterone + UDP-glucuronate isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics Homo sapiens UDP + testosterone 17-O-glucuronide
-
 ?