Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F90A | isoform 1A10, complete loss of activity to substrates 6- and 7-hydroxywarfarin, no change in activity to 8-hydroxywarfarin | Homo sapiens |
F93A | increase in turnover rates for substrates 6- and 7-hydroxywarfarin, substrate inhibition kinetics | Homo sapiens |
V92A | increase in turnover rates for substrates 6- and 7-hydroxywarfarin, substrate inhibition kinetics | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-hydroxywarfarin | competitive | Homo sapiens | |
7-hydroxywarfarin | competitive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.17 | - |
7-hydroxywarfarin | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.19 | - |
8-hydroxywarfarin | mutant F90A, pH 7.4, 37°C | Homo sapiens | |
0.304 | - |
8-hydroxywarfarin | mutant F93A, pH 7.4, 37°C | Homo sapiens | |
0.39 | - |
8-hydroxywarfarin | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.39 | - |
8-hydroxywarfarin | mutant V92A, pH 7.4, 37°C | Homo sapiens | |
0.48 | - |
6-hydroxywarfarin | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.56 | - |
7-hydroxywarfarin | mutant V92A, pH 7.4, 37°C | Homo sapiens | |
0.7 | - |
6-hydroxywarfarin | mutant V92A, pH 7.4, 37°C | Homo sapiens | |
0.72 | - |
6-hydroxywarfarin | mutant F93A, pH 7.4, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-hydroxywarfarin + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
7-hydroxywarfarin + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
8-hydroxywarfarin + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1A10 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.82 | - |
6-hydroxywarfarin | mutant F93A, pH 7.4, 37°C | Homo sapiens | |
1.1 | - |
6-hydroxywarfarin | mutant V92A, pH 7.4, 37°C | Homo sapiens | |
1.1 | - |
7-hydroxywarfarin | mutant V92A, pH 7.4, 37°C | Homo sapiens |