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BRENDA support

Literature summary for 2.4.1.17 extracted from

  • Mitra, P.S.; Basu, N.K.; Owens, I.S.
    Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer (2009), Biochem. Biophys. Res. Commun., 382, 651-656.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Src overexpression of regular or active Src, but not dominant-negative Src, in UGT2B7-transfected COS-1 cells increases UGT2B7 activity and phospho-Y438-2B7 by 50%. UGT2B7 and regular SrcTK are co-localized in COS-1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information UGT2B7 mutants at protein kinase C-sites have essentially normal activity Homo sapiens
S132A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
S132A/S437A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
S437A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
T123A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
T123A/S132A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
T123A/S132A/S437A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
T123A/S437A protein kinase C-site mutant, activity similar to wild-type Homo sapiens
Y236F tyrosine kinase-sites mutants, inactive Homo sapiens
Y438F tyrosine kinase-sites mutants, inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform UGT2B7
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-epiestriol + UDP-glucuronate
-
Homo sapiens UDP + ?
-
?
4-hydroxyestrone + UDP-glucuronate
-
Homo sapiens UDP + 4-hydroxyestrone 4-O-glucuronide
-
?