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Literature summary for 2.4.1.17 extracted from

  • Chouinard, S.; Yueh, M.F.; Tukey, R.H.; Giton, F.; Fiet, J.; Pelletier, G.; Barbier, O.; Belanger, A.
    Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling (2008), J. Steroid Biochem. Mol. Biol., 109, 247-253.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic tree of the 18 human UDP-glucuronosyltransferases Homo sapiens

Protein Variants

Protein Variants Comment Organism
D85Y naturally occuring polymorphism in UGT2B15 gene, Vmax of the Y allele is approximately twofold greater than the enzyme resulting from the D allele Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview ?
-
?
UDP-D-glucuronate + acceptor Homo sapiens conjugation by UDP-glucuronosyltransferase is the major pathway of androgen metabolism and elimination in the human UDP + acceptor beta-D-glucuronoside
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol Homo sapiens isozyme UGT2B15 in the liver UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol Homo sapiens isozyme UGT2B17 in the liver UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol Homo sapiens isozyme UGT2B7in the liver UDP + ?
-
?
UDP-D-glucuronate + androsterone Homo sapiens isozyme UGT2B15 in the liver UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone Homo sapiens isozyme UGT2B17 in the liver UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone Homo sapiens isozyme UGT2B7in the liver UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone Homo sapiens isozyme UGT2B15in the liver UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone Homo sapiens isozyme UGT2B17in the liver UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
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?
UDP-D-glucuronate + dehydrotestosterone Homo sapiens isozyme UGT2B7in the liver UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme UGT2B17
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Homo sapiens P16662 isozyme UGT2B7; isozyme UGT2B7
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Homo sapiens P54855 isozyme UGT2B15; isozyme UGT2B15
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Source Tissue

Source Tissue Comment Organism Textmining
liver isozyme UGT2B7 Homo sapiens
-
liver isozyme UGT2B15 Homo sapiens
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liver isozyme UGT2B17 Homo sapiens
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prostate isozyme UGT2B15, immunohistochemic analysis of isozyme distribution, UGT2B15 occurs in luminal epithelial cells, overview Homo sapiens
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prostate isozyme UGT2B17, immunohistochemic analysis of isozyme distribution, overview Homo sapiens
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skin isozyme UGT2B15 Homo sapiens
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skin isozyme UGT2B17 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview Homo sapiens ?
-
?
UDP-D-glucuronate + acceptor
-
Homo sapiens UDP + acceptor beta-D-glucuronoside
-
?
UDP-D-glucuronate + acceptor conjugation by UDP-glucuronosyltransferase is the major pathway of androgen metabolism and elimination in the human Homo sapiens UDP + acceptor beta-D-glucuronoside
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B15 Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B17 Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B7 Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B15 in the liver Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B17 in the liver Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol isozyme UGT2B7in the liver Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B15 Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B17 Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B7 Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B15 in the liver Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B17 in the liver Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + androsterone isozyme UGT2B7in the liver Homo sapiens UDP + androsterone 3-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B15 Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B17 Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B7 Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B15in the liver Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B17in the liver Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?
UDP-D-glucuronate + dehydrotestosterone isozyme UGT2B7in the liver Homo sapiens UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT
-
Homo sapiens