Cloned (Comment) | Organism |
---|---|
phylogenetic tree of the 18 human UDP-glucuronosyltransferases | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D85Y | naturally occuring polymorphism in UGT2B15 gene, Vmax of the Y allele is approximately twofold greater than the enzyme resulting from the D allele | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview | ? | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | conjugation by UDP-glucuronosyltransferase is the major pathway of androgen metabolism and elimination in the human | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | isozyme UGT2B15 in the liver | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | isozyme UGT2B17 in the liver | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | isozyme UGT2B7in the liver | UDP + ? | - |
? | |
UDP-D-glucuronate + androsterone | Homo sapiens | isozyme UGT2B15 in the liver | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | Homo sapiens | isozyme UGT2B17 in the liver | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | Homo sapiens | isozyme UGT2B7in the liver | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | Homo sapiens | isozyme UGT2B15in the liver | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | Homo sapiens | isozyme UGT2B17in the liver | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | Homo sapiens | isozyme UGT2B7in the liver | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme UGT2B17 | - |
Homo sapiens | P16662 | isozyme UGT2B7; isozyme UGT2B7 | - |
Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | isozyme UGT2B7 | Homo sapiens | - |
liver | isozyme UGT2B15 | Homo sapiens | - |
liver | isozyme UGT2B17 | Homo sapiens | - |
prostate | isozyme UGT2B15, immunohistochemic analysis of isozyme distribution, UGT2B15 occurs in luminal epithelial cells, overview | Homo sapiens | - |
prostate | isozyme UGT2B17, immunohistochemic analysis of isozyme distribution, overview | Homo sapiens | - |
skin | isozyme UGT2B15 | Homo sapiens | - |
skin | isozyme UGT2B17 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | conjugation by UDP-glucuronosyltransferase is the major pathway of androgen metabolism and elimination in the human | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B15 | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B17 | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B7 | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B15 in the liver | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B17 in the liver | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | isozyme UGT2B7in the liver | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B15 | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B17 | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B7 | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B15 in the liver | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B17 in the liver | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | isozyme UGT2B7in the liver | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B15 | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B17 | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B7 | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B15in the liver | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B17in the liver | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dehydrotestosterone | isozyme UGT2B7in the liver | Homo sapiens | UDP + dehydrotestosterone 17-O-beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |