Cloned (Comment) | Organism |
---|---|
expression of isozyme UGT1A10 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A1 isozyme as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A3 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A4 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A6 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A7 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A8 as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
expression of UGT1A9 isozyme as HA-tagged or CFP-fusion protein in COS cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A enzyme, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A enzyme, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A1, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A1, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A10, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A10, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A3, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A3, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A6, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A6, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A7, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A7, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A8, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A8, SDS-PAGE | Homo sapiens |
56000 | - |
x * 86000, CFP-tagged recombinant UGT1A9, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A9, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A enzyme, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A enzyme, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A1, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A1, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A10, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A10, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A3, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A3, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A6, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A6, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A7, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A7, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A8, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A8, SDS-PAGE | Homo sapiens |
86000 | - |
x * 86000, CFP-tagged recombinant UGT1A9, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A9, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity | ? | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | UDP-glucuronosyltransferases are membrane-bound proteins localized to the endoplasmic reticulum and catalyze the formation of beta-D-glucopyranosiduronic acids using UDP-D-glucuronic acid and acceptor substrates such as drugs, steroids, bile acids, xenobiotics, and dietary nutrients | UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | isozyme UGT1A9; isozyme UGT1A9 | - |
Homo sapiens | P19224 | isozyme UGT1A6; isozyme UGT1A6 | - |
Homo sapiens | P22309 | isozyme UGT1A1; isozyme UGT1A1 | - |
Homo sapiens | P22310 | isozyme UGT1A4; isozyme UGT1A4 | - |
Homo sapiens | P35503 | isozyme UGT1A3; isozyme UGT1A3 | - |
Homo sapiens | Q9HAW7 | isozyme UGT1A7; isozyme UGT1A7 | - |
Homo sapiens | Q9HAW8 | isozyme UGT1A10; isozyme UGT1A10 | - |
Homo sapiens | Q9HAW9 | isozyme UGT1A8; isozyme UGT1A8 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + 2-naphthol | isozyme UGT1A7 | Homo sapiens | UDP + 2-naphthyl beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | UDP-glucuronosyltransferases are membrane-bound proteins localized to the endoplasmic reticulum and catalyze the formation of beta-D-glucopyranosiduronic acids using UDP-D-glucuronic acid and acceptor substrates such as drugs, steroids, bile acids, xenobiotics, and dietary nutrients | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + octylgallate | isozyme UGT1A1 | Homo sapiens | UDP + octylgallate beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + octylgallate | isozyme UGT1A3 | Homo sapiens | UDP + octylgallate beta-D-glucuronoside | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 86000, CFP-tagged recombinant UGT1A enzyme, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A enzyme, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A1, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A1, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A10, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A10, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A3, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A3, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A6, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A6, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A7, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A7, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A8, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A8, SDS-PAGE | Homo sapiens |
? | x * 86000, CFP-tagged recombinant UGT1A9, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A9, SDS-PAGE | Homo sapiens |
More | isozyme UGT1A1 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with isozymes UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 to form heterodimers | Homo sapiens |
More | isozyme UGT1A10 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A10 to form heterodimers | Homo sapiens |
More | isozyme UGT1A3 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A3 to form heterodimers | Homo sapiens |
More | isozyme UGT1A4 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A4 to form heterodimers | Homo sapiens |
More | isozyme UGT1A6 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A6 to form heterodimers | Homo sapiens |
More | isozyme UGT1A7 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A7 to form heterodimers | Homo sapiens |
More | isozyme UGT1A8 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A8 to form heterodimers | Homo sapiens |
More | isozyme UGT1A9 self-oligomerizes to homodimers. Isozyme UGT1A1 is capable of binding with UGT1A9 to form heterodimers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
UGT1A10 | - |
Homo sapiens |
UGT1A3 | - |
Homo sapiens |
UGT1A4 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
UGT1A7 | - |
Homo sapiens |
UGT1A8 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |