KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
estradiol | pH 7.4, 37°C | Rattus norvegicus | |
0.042 | - |
estradiol | pH 7.4, 37°C | Mus musculus | |
0.164 | - |
4-Methylumbelliferone | pH 7.4, 37°C | Mus musculus | |
0.32 | - |
morphine | pH 7.4, 37°C | Rattus norvegicus | |
0.34 | - |
mycophenolate | pH 7.4, 37°C | Rattus norvegicus | |
0.416 | - |
4-Methylumbelliferone | pH 7.4, 37°C | Rattus norvegicus | |
0.494 | - |
4-nitrophenol | above, pH 7.4, 37°C | Rattus norvegicus | |
1.272 | - |
mycophenolate | pH 7.4, 37°C | Mus musculus | |
1.5 | - |
4-nitrophenol | above, pH 7.4, 37°C | Mus musculus | |
2.38 | - |
morphine | pH 7.4, 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview | ? | - |
? | |
additional information | Rattus norvegicus | comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview | ? | - |
? | |
UDP-D-glucuronate + 4-nitrophenol | Mus musculus | - |
UDP + 4-nitrophenyl O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 4-nitrophenol | Rattus norvegicus | - |
UDP + 4-nitrophenyl O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Mus musculus | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Rattus norvegicus | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estradiol | Mus musculus | - |
UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estradiol | Rattus norvegicus | - |
UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | Mus musculus | - |
UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | Rattus norvegicus | - |
UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + mycophenolate | Mus musculus | - |
UDP + ? | - |
? | |
UDP-D-glucuronate + mycophenolate | Rattus norvegicus | - |
UDP + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mic, BALB/c, C3H/HeJ, DBA/2, ddY, and ICR mice | - |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Mus musculus | - |
colon | - |
Rattus norvegicus | - |
duodenum | - |
Mus musculus | - |
duodenum | - |
Rattus norvegicus | - |
ileum | - |
Mus musculus | - |
ileum | - |
Rattus norvegicus | - |
jejunum | - |
Mus musculus | - |
jejunum | - |
Rattus norvegicus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview | Mus musculus | ? | - |
? | |
additional information | comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview | Rattus norvegicus | ? | - |
? | |
UDP-D-glucuronate + 4-methylumbelliferone | - |
Mus musculus | UDP + 4-methylumbelliferyl beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 4-methylumbelliferone | - |
Rattus norvegicus | UDP + 4-methylumbelliferyl beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 4-nitrophenol | - |
Mus musculus | UDP + 4-nitrophenyl O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 4-nitrophenol | - |
Rattus norvegicus | UDP + 4-nitrophenyl O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Mus musculus | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Rattus norvegicus | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estradiol | - |
Mus musculus | UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estradiol | - |
Rattus norvegicus | UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | - |
Mus musculus | UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | - |
Rattus norvegicus | UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + mycophenolate | - |
Mus musculus | UDP + ? | - |
? | |
UDP-D-glucuronate + mycophenolate | - |
Rattus norvegicus | UDP + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Mus musculus |
UDP-glucuronosyltransferase | - |
Rattus norvegicus |
UGT | - |
Mus musculus |
UGT | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Rattus norvegicus |