Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alamethicin | a pore-forming peptide, activates the activity of liver microsomes, but not of purified recombinant isozyme, with substrates dexmedetomidine and levomedetomidine | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis, recombinant isozyme UGT1A4, and liver microsomes, with substrates dexmedetomidine and levomedetomidine, overview | Homo sapiens | |
additional information | - |
additional information | kinetic analysis, recombinant isozyme UGT2B10, and liver microsomes, with substrates dexmedetomidine and levomedetomidine, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 UDP-D-glucuronate + 2 dexmedetomidine | Homo sapiens | the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides | 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 levomedetomidine | Homo sapiens | the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide | 2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme UGT1A4 | - |
Homo sapiens | P36537 | isozyme UGT2B10 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 UDP-D-glucuronate + 2 dexmedetomidine | the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides | Homo sapiens | 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 dexmedetomidine | i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, overview | Homo sapiens | 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 dexmedetomidine | i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, overview | Homo sapiens | 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 levomedetomidine | the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide | Homo sapiens | 2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 levomedetomidine | i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, isozyme UGT1A4 shows low activity producing N1- and N3-glucuronides, overview | Homo sapiens | 2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
2 UDP-D-glucuronate + 2 levomedetomidine | i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, isozyme UGT2B10 exclusively produces N3-glucuronides, overview | Homo sapiens | 2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside | - |
? | |
additional information | regioselectivity of recombinant isozymes and liver microsomes, overview | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP glucuronosyltransferase 1A4 | - |
Homo sapiens |
UDP glucuronosyltransferase 2B10 | - |
Homo sapiens |
UGT1A4 | - |
Homo sapiens |
UGT2B10 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |