Cloned (Comment) | Organism |
---|---|
expression of isozyme UGT2B7 as a His-tagged protein in baculovirus-infected insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid | - |
Homo sapiens | |
((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid | - |
Homo sapiens | |
((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid | - |
Homo sapiens | |
((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid | - |
Homo sapiens | |
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol | - |
Homo sapiens | |
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol | - |
Homo sapiens | |
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol | - |
Homo sapiens | |
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol | - |
Homo sapiens | |
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethan | - |
Homo sapiens | |
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol | - |
Homo sapiens | |
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol | - |
Homo sapiens | |
(1R)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1R)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
(1R)-2-methyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1R)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1S)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol | - |
Homo sapiens | |
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol | - |
Homo sapiens | |
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol | - |
Homo sapiens | |
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol | - |
Homo sapiens | |
(1S)-2,2-dimethyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1S)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(1S)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
(1S)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
(2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid | - |
Homo sapiens | |
(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol | - |
Homo sapiens | |
(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid | - |
Homo sapiens | |
(2R)-3,3-dimethyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol | - |
Homo sapiens | |
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-2-ol | - |
Homo sapiens | |
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol | - |
Homo sapiens | |
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]pent-4-en-2-ol | - |
Homo sapiens | |
(2S)-3-methyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol | - |
Homo sapiens | |
(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol | - |
Homo sapiens | |
(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid | - |
Homo sapiens | |
(3-(dimethylamino)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid | - |
Homo sapiens | |
(3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid | - |
Homo sapiens | |
(3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid | - |
Homo sapiens | |
(3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid | - |
Homo sapiens | |
(3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid | - |
Homo sapiens | |
(3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid | - |
Homo sapiens | |
(4-(dimethylamino)-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butyl)phosphonic acid | - |
Homo sapiens | |
(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid | - |
Homo sapiens | |
(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid | - |
Homo sapiens | |
(R)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol | - |
Homo sapiens | |
(S)-phenyl[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol | - |
Homo sapiens | |
(S)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol | - |
Homo sapiens | |
2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-2-ol | - |
Homo sapiens | |
2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol | - |
Homo sapiens | |
3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol | - |
Homo sapiens | |
4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol | - |
Homo sapiens | |
4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid | - |
Homo sapiens | |
4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol | - |
Homo sapiens | |
4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid | - |
Homo sapiens | |
diethyl ((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate | - |
Homo sapiens | |
diethyl ((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate | - |
Homo sapiens | |
diethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate | - |
Homo sapiens | |
diethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate | - |
Homo sapiens | |
dimethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate | - |
Homo sapiens | |
dimethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate | - |
Homo sapiens | |
ethyl (3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate | - |
Homo sapiens | |
ethyl (3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate | - |
Homo sapiens | |
ethyl (3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate | - |
Homo sapiens | |
ethyl (3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate | - |
Homo sapiens | |
isolongifolol | and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview | Homo sapiens | |
longifolol | and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview | Homo sapiens | |
additional information | detailed structure-activity relationships, the glucuronidation of substrate compounds is prevented by the introduction of bulky substituents such as isopropyl, tert-butyl, and phenyl groups, overview | Homo sapiens | |
[(1E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-1-en-1-yl]phosphonic acid | - |
Homo sapiens | |
[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid | - |
Homo sapiens | |
[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol | - |
Homo sapiens | |
[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid | - |
Homo sapiens | |
[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol | - |
Homo sapiens | |
[(E)-2-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)ethenyl]phosphonic acid | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme UGT2B7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | detailed structure-activity relationships with respect to functionality, stereochemical properties, and steric features, with 3D-quantitative structure-activity relationship using comparative molecular similarity analysis, overview. The glucuronidation of substrate compounds is prevented by the introduction of bulky substituents such as isopropyl, tert-butyl, and phenyl groups, overview | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estriol | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + isolongifolol | the compound is substrate and competitive inhibitor | Homo sapiens | UDP + isolongifolol beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + longifolol | the compound is substrate and competitive inhibitor | Homo sapiens | UDP + longifolol beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000023 | - |
isolongifolol | - |
Homo sapiens | |
0.000026 | - |
longifolol | - |
Homo sapiens |