Cloned (Comment) | Organism |
---|---|
expression in Cos-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S432G | mutant enzyme retains full activity, shift in pH-optimum for glucuronidation of eugenol from pH 6.0 for wild-type enzyme to 6.4 for mutant enzyme S432G | Homo sapiens |
S432G | shift in pH-optimum for glucuronidation of eugenol from pH 8.5 for wild-type enzyme to 6.4 for mutant enzyme S432G. S432G-UGT1A7, but not wild-type UGT1A7, metabolizes new substrates, 17beta-estradiol, flurbiprofen, and estriol | Homo sapiens |
T202A | inactive mutant enzyme | Homo sapiens |
T73A | inactive mutant enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HAW7 | - |
- |
Homo sapiens | Q9HAW8 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of a UDP-glucuronosyltransferase by protein kinase C regulates substrate specificity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + UDP-glucuronate | metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 | Homo sapiens | ? | - |
? | |
estriol + UDP-glucuronate | metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 | Homo sapiens | ? | - |
? | |
eugenol + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
eugenol + UDP-glucuronate | - |
Homo sapiens | UDP + eugenol-O-alpha-D-glucuronide | - |
? | |
flurbiprofen + UDP-glucuronate | metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UGT1A10 | - |
Homo sapiens |
UGT1A7 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
substrate: eugenol, wild-type enzyme | Homo sapiens |
6.4 | - |
substrate: eugenol, mutant enzyme S432G | Homo sapiens |
8.5 | - |
substrate: eugenol, wild-type enzyme | Homo sapiens |