Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-demethyltranilast | - |
Homo sapiens | |
4-demethyltranilast | bilirubin glucuronosyltransferase activity, tranilast glucuronosyltransferase activity | Homo sapiens | |
bilirubin | tranilast glucuronosyltransferase activity, activity in human jejunum microsomes is strongly inhibited (IC50: 0.0811 mM) | Homo sapiens | |
tranilast | bilirubin glucuronosyltransferase activity, activity in human jejunum microsomes is strongly inhibited (0.0753 mM) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0506 | - |
tranilast | activity in human jejunum microsomes | Homo sapiens | |
0.0515 | - |
tranilast | activity in human liver microsomes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22309 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
jejunum | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + UDP-glucuronate | UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein) | Homo sapiens | bilirubin glucuronoside + UDP | - |
? | |
tranilast + UDP-glucuronate | - |
Homo sapiens | tranilast glucuronoside + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UGT1A1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0811 | - |
tranilast glucuronosyltransferase activity, activity in human jejunum microsomes is strongly inhibited (IC50: 0.0811 mM) | Homo sapiens | bilirubin |