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Literature summary for 2.4.1.17 extracted from
- Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7 (2007), Biochem. Pharmacol., 73, 1683-1691.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Flufenamic acid | 0.02-0.5 mM, completely inhibits glucuronidation of 4-methylumbelliferone; 0.02-0.5 mM, inhibits glucuronidation of 4-methylumbelliferone | Homo sapiens |  |
| Mefenamic acid | 0.02-0.5 mM, completely inhibits glucuronidation of 4-methylumbelliferone; 0.02-0.5 mM, inhibits glucuronidation of 4-methylumbelliferone | Homo sapiens | |
| niflumic acid | 0.02-0.5 mM, 66% inhibition of glucuronidation of 4-methylumbelliferone; 0.02-0.5 mM, inhibits glucuronidation of 4-methylumbelliferone | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.048 | - |
Flufenamic acid | - |
Homo sapiens | |
| 0.135 | - |
niflumic acid | - |
Homo sapiens | |
| 0.449 | - |
Mefenamic acid | - |
Homo sapiens | |
| 7.344 | - |
niflumic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60656 | - |
- |
| Homo sapiens | P16662 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | cortex | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide | - |
? | |
| UDP-glucuronate + flufenamic acid | - |
Homo sapiens | ? | - |
? | |
| UDP-glucuronate + mefenamic acid | - |
Homo sapiens | ? | - |
? | |
| UDP-glucuronate + niflumic acid | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3,4-catechol estrogen specific UDPGTh-2 | - |
Homo sapiens |
| UFT1A9 | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
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