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Literature summary for 2.4.1.17 extracted from

  • Lepine, J.; Bernard, O.; Plante, M.; Tetu, B.; Pelletier, G.; Labrie, F.; Belanger, A.; Guillemette, C.
    Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium (2004), J. Clin. Endocrinol. Metab., 89, 5222-5232.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of UGT1A and UGT2B isozymes in HEK293 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information different kinetic profiles of isozymes with different hormone substrates, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes UGT1A1, UGT1A3, UGT1A8, UGT1A9, UGT1A10, and UGT2B7
-

Source Tissue

Source Tissue Comment Organism Textmining
uterine endometrium isozyme UGT2B7 Homo sapiens
-
uterus isozyme UGT2B7 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyestrone + UDP-glucuronate
-
Homo sapiens UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
-
?
additional information isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates Homo sapiens ?
-
?
UDP-glucuronate + 2-hydroxyestrone
-
Homo sapiens UDP + 2-hydroxyestrone beta-D-glucuronide
-
?
UDP-glucuronate + 2-methoxyestrone
-
Homo sapiens UDP + 2-methoxyestrone beta-D-glucuronide
-
?
UDP-glucuronate + 4-methoxyestrone
-
Homo sapiens UDP + 4-methoxyestrone beta-D-glucuronide
-
?
UDP-glucuronate + estradiol
-
Homo sapiens UDP + estradiol beta-D-glucuronide
-
?
UDP-glucuronate + estrone
-
Homo sapiens UDP + estrone beta-D-glucuronide
-
?

Synonyms

Synonyms Comment Organism
UGT
-
Homo sapiens
uridine diphosphate glucuronosyltransferase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens