Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azidothymidine | selective for isozyme UGT2B7 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of microsomes from different tissues | Homo sapiens | |
0.16 | - |
Mycophenolic acid | isozyme UGT1A9 | Homo sapiens | |
0.18 | - |
Mycophenolic acid | liver microsomes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + mycophenolic acid | Homo sapiens | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
UDP-glucuronate + mycophenolic acid | Homo sapiens | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | UDP + mycophenolic acid-phenyl-glucuronide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes UGT1A9 and UGT2B7, renal transplant patients under mycopenolate mofetil therapy | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | mucosa, isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
kidney | isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
liver | isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
mucosa | intestinal, isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + mycophenolic acid | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | Homo sapiens | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
UDP-glucuronate + mycophenolic acid | isozymes UGT1A9 and UGT2B7 | Homo sapiens | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
UDP-glucuronate + mycophenolic acid | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | Homo sapiens | UDP + mycophenolic acid-phenyl-glucuronide | - |
? | |
UDP-glucuronate + mycophenolic acid | isozymes UGT1A9 and UGT2B7 | Homo sapiens | UDP + mycophenolic acid-phenyl-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |