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Literature summary for 2.4.1.17 extracted from

  • Vallee, M.; Albert, C.; Beaudry, G.; Hum, D.W.; Belanger, A.
    Isolation and characterization of the monkey UDP-glucuronosyltransferase cDNA clone monUGT1A01 active on bilirubin and estrogens (2001), J. Steroid Biochem. Mol. Biol., 77, 239-249.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
UGT1A1 expressed in HK-293 cells Platyrrhini
UGT1A1 expressed in HK293 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
2-hydroxyestradiol
-
Platyrrhini
6
-
2-hydroxyestrone
-
Platyrrhini
13
-
estradiol
-
Platyrrhini

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Platyrrhini
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
UGT1 proteins by Western Blot Homo sapiens
55000
-
UGT1 proteins by Western Blot Platyrrhini

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Platyrrhini
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyestradiol + UDP-glucuronate
-
Platyrrhini UDP + 2-hydroxyestradiol O-glucuronide
-
?
2-hydroxyestrone + UDPglucuronate
-
Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP
-
?
2-hydroxyestrone + UDPglucuronate
-
Platyrrhini 2-hydroxyestrone 2-O-glucuronide + UDP
-
?
estradiol + UDPglucuronate
-
Platyrrhini UDP + estradiol O-glucuronide
-
?